Factors associated with death among hospitalized COVID-19 patients in Lagos State, Nigeria: a retrospective cross-sectional study

Background: Lagos State has the highest burden of COVID-19 in Nigeria. We assessed associated factors with death from COVID-19 among hospitalized patients in Lagos, Nigeria. Methods: A retrospective cross-sectional study was conducted using de-identified records of laboratory-confirmed COVID-19 patients admitted into 15 isolation centers in Lagos State between February 27, 2020, and September 30, 2020. Results: A total of 2,858 COVID -19 patients were included in this study. The mean age of the patients was 41.9±15.5 years. A higher proportion of patients were males (65.8%), asymptomatic (55.5%), had no comorbid condition (72.2%) and had the mild disease (73.8%). The case fatality rate was 6.5%. The odds of death from COVID-19 infection increased by 4% with every increase in age (AOR 1.04, 95%CI 1.03­1.05, p<0.001). The chance of dying was 50%-fold more among males (AOR 1.5, 95%CI 1.0 ­ 2.2, p = 0.042), 60%-fold more among patients with comorbidity (AOR 1.6, 95%CI 1.3 ­ 2.4, p = 0.037) and 9-fold more among patients with severe COVID-19 infection (AOR 9.6, 95% CI 4.9 ­ 19.1, p <0.001). Conclusion: The odds of dying was higher among males, the elderly, patients with comorbidity and severe COVID-19